<tc>CBD in cancer management: CBD benefits</tc>

Today, doctors and pharmacists approach CBD as a promising anti-cancer component that can significantly improve the quality of life for people suffering from oncological diseases. Let’s take a closer look at the medicinal and therapeutic properties and benefits of CBD for patients.

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    Note: This and other articles on Hempo's blog are for informational purposes only. According to the directive of the European Commission, cannabidiol is classified as a 'novel food', therefore CBD products should not be used as a food supplement in Lithuania.

    CBD for cancer: what is it?

    Hemp plants consist of hundred compounds called cannabinoids. CBD (cannabidiol) extracted from hemp is the second most popular cannabinoid in the world, second only to tetrahydrocannabinol (THC), a cannabinoid with hallucinogenic properties.

    Unlike THC, cannabidiol does not cause intoxication or other adverse reactions. CBD has calming effects and anti-inflammatory properties, so it’s used very widely. CBD oil is used in cosmetics, e.g. to improve skin condition, treat acne, reduce wrinkles, strengthen thinning hair, etc., and for medical purposes, e.g. to treat anxiety disorders, insomnia, depression, eating disorders, chronic diseases and oncological diseases.

    CBD oil for cancer treatment

    CBD and the endocannabinoid system

    The health benefits of CBD have been known for decades. CBD research and product development was further fuelled by the discovery of the human endocannabinoid system (ECS) in the late 1980s.

    The ECS is a complex cell signalling system consisting of cannabinoid receptors and endocannabinoids. The endocannabinoid system is found throughout the body, organs and tissues, but its activity is manifested in the central and peripheral nervous systems.

    The endocannabinoid system helps regulate many vital physiological functions, such as sleep, mood (hormone balance), appetite, emotions and pain perception. CBD interacts with the human body through ECS receptors and the entire endocannabinoid system.

    Oncology and CBD: what should you know?

    Cancer is an aggressive and often difficult to treat disease that is caused by hereditary, environmental and lifestyle factors. With cancer and other oncological diseases, the treatment process is often long and complicated. Even patients receiving the best medical care still experience many unwanted, distressing side symptoms.

    However, progress in the treatment of oncological diseases is made every day: new treatments are constantly being developed and improved in Lithuania and around the world. CBD is no exception. The use of this cannabinoid in the treatment of cancer has been of interest to the medical and scientific community for some time. CBD products have already shown that they can help cancer patients manage some of the symptoms, alleviate the side effects of treatment and strengthen their weakened immune systems.

    Also, researchers from different disciplines are currently investigating whether CBD oil could slow down or completely stop cancer. Although there is still a lot of work to be done in this area, research shows great promise for CBD.

    CBD oil for oncology

    Is CBD for Cancer Safe?

    There are numerous personal accounts on the internet discussing the benefits of CBD in fighting cancer and reducing the side effects of chemotherapy. However, it is essential to remember that such personal stories do not provide comprehensive scientific validation of CBD as a treatment for cancer. The safety and efficacy of CBD for cancer patients have not yet been thoroughly confirmed through large-scale or randomized clinical trials.

    If you are considering using CBD for cancer, it is crucial to consult with your oncologist before starting CBD. Given that the effectiveness of CBD for cancer is not yet scientifically confirmed, discussing the use of CBD for cancer with your doctor will help you assess all the factors related to CBD use, such as interactions with other medications and proper dosing.

    Does CBD for Cancer Have Side Effects?

    Regarding the potential side effects of CBD for cancer, it is important to mention the impact of CBD oil on liver function. The warning label of "Epidiolex," a medication containing CBD used to treat epilepsy, indicates that CBD oil can adversely affect the liver.

    Scientific studies show that CBD interferes with the activity of certain enzymes, such as CYP2D6 and CYP3A4, which are crucial for drug metabolism. This can negatively impact the effectiveness and safety of medications and influence their tolerance in the body. Such effects are particularly significant when using chemotherapy and other medications, so it is crucial for people considering CBD for cancer to take this into account.

    It is important to remember that CBD oil is not considered a medication - it is a supplement aimed at improving various health conditions or medical issues. For this reason, people with cancer or other diseases often do not inform their doctors before starting CBD oil. It is essential to understand that CBD oil can have harmful side effects, especially when combined with certain medications, making it crucial to inform your doctor about CBD oil use.

    Benefits of CBD for patients

    Cancer and cancer treatments such as chemotherapy and radiotherapy can have multiple side effects, including nausea and vomiting, loss of appetite and pain. There are many medications on the market to manage unpleasant symptoms, but not infrequently these medications also have their own side effects, leaving the side effects of cancer treatment a constant challenge and a significant physical and emotional burden for patients.

    Here are the benefits that regular use of high-quality CBD oil can provide:

    1. Stimulating appetite. Doctors point out that many cancer patients complain of loss of appetite or even eating disorders. They suffer from changes in taste, nausea or vomiting, making it difficult to enjoy food. CBD oil can reduce nausea and vomiting while stimulating appetite. Many patients who regularly use CBD products begin to enjoy the food much more, gain some weight and feel better overall;

    2. Relieving pain. CBD works as an anti-inflammatory and pain reliever. It could benefit to people with oncological diseases, who often suffer from pain in various body parts, numb legs and other unpleasant physical sensations caused by the disease and the treatment;

    3. Improving emotional well-being. The scientific publication The Permanente Journal wrote about a study involving 72 patients. It found that as much as 79% of patients who regularly used CBD for a month experienced improving symptoms of anxiety. 66% of patients reported that their sleep quality and overall emotional well-being had improved. These results are associated with the positive effects of CBD on the receptors of the endocannabinoid system;

    4. Slowing the growth of tumors. Studies show that CBD oil can slow the growth of certain tumors. It is associated with the apotheosis-promoting effects of CBD. Apotheosis is a genetically programmed cell death. Apotheosis occurs when a cell becomes useless or dangerous to the body. In cancer, the processes of apotheosis slow down, but CBD can stimulate the self-destruction of cancer cells. In this way, the growth of tumors is significantly slower.

    Cannabinoid and Cancer Research

    To understand whether hemp and its chemical compounds can genuinely aid in cancer treatment, more research is required. This involves conducting clinical trials with larger numbers of patients, where some patients will receive the treatment while others will not. Such studies will be crucial in the future to definitively determine the effectiveness of CBD in treating cancer.

    So far, most studies investigating the effectiveness of CBD against cancer have been small-scale and conducted in laboratories. However, it is worth noting that there have been some significant studies involving cancer patients. For example, in 2021, the results of a Phase 1 trial for the drug Sativex (which contains cannabidiol) aimed at recurrent brain tumors, specifically glioblastoma, were published. This trial examined the effects of these drugs when used in conjunction with chemotherapy. The results revealed that Sativex caused side effects such as vomiting, dizziness, fatigue, nausea, and headaches in cancer patients. Nevertheless, patients reported these side effects as tolerable.

    Interestingly, a year later, 83% of the patients who used Sativex were still alive, compared to 44% of those who were given a placebo. Despite this promising outcome, the Phase 1 trial involved only 27 patients, making it difficult to draw definitive conclusions about the benefits of Sativex. The primary goal of the trial was to determine whether it is safe to use Sativex in combination with temozolomide.
    CBD for cancer

    CBD for cancer: prospects of the medication

    Currently, the scientific community has conducted several preclinical in vitro and in vivo studies that support the assumption that cannabinoids, including CBD, have anticancer effects and can be used in the treatment of various types of cancer. CBD helps destroy cancer cells and can prevent their reproduction and growth.

    For example, the potential of CBD in breast cancer treatment has been studied for years. Tests in mice have shown consistent effectiveness of cannabidiol on many different breast cancer cells. It’s important because breast cancer is one of the most common forms of cancer. It’s also a fairly common cause of death in women. However, the therapeutic effects of CBD are likely to be applied to many other types of cancer, including brain tumors, pancreatic, prostate, colorectal, lymphoma, etc.

    And this is not the only potential anti-cancer effect of CBD. It is claimed that CBD oil not only affects cancer cells directly, but also interacts with the environment of a tumor or other cancerous formation: it stops the development of blood cells that feed the cancer, prevents them from spreading and reduces inflammatory processes in the affected organs and the whole body.

    Moreover, despite its activity against cancer cells, CBD oil has no negative effects on normal cells in tissues and organs affected by cancer. It means that patients would probably not experience severe side effects when using CBD-based medications.

    Although research on CBD as a medicine is currently at a very early stage, one thing is clear – CBD’s mild but sure effects make it a promising anti-cancer agent.

    CBD for cancer: summary

    This article discusses the potential benefits of CBD (cannabidiol) for cancer patients, highlighting its therapeutic and curative properties. CBD, derived from hemp, is a non-poisonous cannabinoid with sedative and anti-inflammatory properties. It is widely used in both cosmetic and medical applications, including oncological diseases. The health benefits of CBD against cancer are linked to the human endocannabinoid system (ECS), a cellular signalling system that regulates vital functions such as sleep, mood, appetite and pain perception. CBD for cancer is being studied for its ability to manage cancer symptoms, mitigate the side effects of treatment and boost the immune system.

    Dažnai užduodami klausimai

    Kokia yra CBD nuo vėžio nauda?

    CBD (kanabidiolio) nauda nuo vėžio apima jo raminantį poveikį, priešuždegimines savybes ir ne tik - moksliniai tyrimai rodo, jog CBD gali būti naudingas vėžio simptomų valdymui ir onkologinių ligų gydymo (chemoterapijos) poveikio švelninimui. CBD, sąveikaudamas su endokanabinoidine sistema (EKS), padeda sumažinti skausmą, gerina nuotaiką ir stiprina imuninės sistemos veiklą.

    Kokia yra CBD nuo vėžio nauda emocinei savijautai?

    Remiantis mokslinių tyrimų duomenimis, CBD gali reikšmingai sumažinti su nerimu susijusius simptomus. CBD gerina miego kokybę, o tai prisideda ir prie bendros emocinės savijautos pagerėjimo.

    Kokia yra CBD nuo vėžio nauda apetitui?

    Ne paslaptis, jog daugelis onkologinėmis ligomis sergančių pacientų skundžiasi prastu apetitu. CBD nuo vėžio gali padėti slopinti skonio pakitimus, pykinimą ir vėmimą, o tai leidžia vėžiu sergantiems žmonėms iš naujo mėgautis maistu. Didesnis apetitas lemia teigiamus kūno svorio pokyčius, pagerėja ir bendra paciento savijauta.

    Ar CBD nuo vėžio yra saugus?

    CBD įprastai yra laikomas saugiu ir gerai toleruojamu didelės dalies suaugusiųjų. Visgi, prieš pradedant naudoti CBD nuo vėžio, svarbu pasikonsultuoti su gydytoju - CBD gali sąveikauti su kai kuriais receptiniais vaistais ir turėti poveikį kepenų funkcijai.

    Kokie yra CBD nuo vėžio šalutiniai poveikiai?

    Galimi CBD nuo vėžio šalutiniai poveikiai apima poveikį kepenų funkcijai, sąveikavimą su kitais vaistais, lengvą nuovargį ar galvos svaigimą. Šie šalutiniai poveikiai dažniausiai būna nežymūs ir laikui bėgant išnyksta - jie priklauso nuo individualios paciento būklės ir CBD dozavimo.